Clinical trial of piracetam in patients with myoclonus: nationwide multiinstitution study in Japan. The Myoclonus/Piracetam Study Group.

Clinical trial of piracetam in patients with myoclonus: nationwide multiinstitution study in Japan. The Myoclonus/Piracetam Study Group.

Ikeda A, Shibasaki H, Tashiro K, Mizuno Y, Kimura J.

Department of Brain Pathophysiology,
Kyoto University School of Medicine, Japan.
Mov Disord 1996 Nov;11(6):691-700

Abstract

Sixty patients with disabling myoclonus excluding mainly spinal myoclonus were treated by piracetam as an open-labeled study, and myoclonus score, neurological symptoms, functional disability, and intensity of myoclonus were scored before and after treatment, including a blinded video inspection.  Electrophysiological correlation also was investigated before and after treatment.  Piracetam was effective in myoclonus, especially that of cortical origin, in both monotherapy and polytherapy. Piracetam also had positive benefits on gait ataxia and convulsions but not on dysarthria, and feeding and hand writing improved much more significantly.  Psychologically significant improvement was seen in decreased motivation, sleep disturbance, attention deficit, and depression, all of which might be possibly secondary benefits associated with improvement of myoclonus.  There was no positive correlation between clinical and electrophysiological improvement.  Tolerance was good, and side effects were transient.  However, hematological abnormalities observed in at least two patients in the present study should be kept in mind when relatively large doses of piracetam are administered, especially in combination with other anti-myoclonic drugs.

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    more} useful than ever before.|
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    {It is|It’s} {appropriate|perfect|the best} time to
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    {Perhaps|Maybe} you {could|can} write {next|subsequent} articles {relating to|referring to|regarding}
    this article. I {want to|wish to|desire to} {read|learn} {more|even more} {things|issues} {approximately|about}
    it!|
    {I have|I’ve} been {surfing|browsing} {online|on-line} {more than|greater than} {three|3} hours {these days|nowadays|today|lately|as of late}, {yet|but} I {never|by no means} {found|discovered} any {interesting|fascinating|attention-grabbing} article like yours. {It’s|It is} {lovely|pretty|beautiful} {worth|value|price} {enough|sufficient} for me.
    {In my opinion|Personally|In my view}, if all {webmasters|site owners|website owners|web owners} and bloggers made {just right|good|excellent} {content|content material} as {you did|you probably did},
    the {internet|net|web} {will be|shall be|might be|will probably be|can
    be|will likely be} {much more|a lot more} {useful|helpful} than ever before.
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    on {Safari|Internet explorer|Chrome|Opera|Firefox}. {Superb|Exceptional|Outstanding|Excellent} Blog!
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    be} up too. {This sort of|This type of|Such|This kind of} clever
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    {|my|our|my personal|my own} blogroll.|
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    mind {stating|sharing} which blog platform you’re {working with|using}? I’m
    {looking|planning|going} to start my own blog {in the near future|soon} but I’m having a {tough|difficult|hard} time {making a decision|selecting|choosing|deciding} between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your {design and style|design|layout} seems different then most blogs and I’m looking for something
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    S {My apologies|Apologies|Sorry} for {getting|being} off-topic
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    browsers|browsers} and I must say this blog loads a lot {quicker|faster}
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    folks|whenever people} {come together|get together} and
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    any {topic|matter} on {net|web} as compared to {books|textbooks}, as I found this {article|post|piece of writing|paragraph} at this {website|web site|site|web page}.
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    when I get home. I’m {shocked|amazed|surprised} at how {quick|fast} your blog loaded on my {mobile|cell phone|phone} .. I’m not even using WIFI,
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    You {seem|appear} {to understand|to know|to grasp} {so much|a lot} {approximately|about} this, {like you|such as you} wrote the
    {book|e-book|guide|ebook|e book} in it or something. {I think|I feel|I believe} {that you|that you simply|that you just} {could|can} do with {some|a few} {%|p.c.|percent} to {force|pressure|drive|power} the message {house|home} {a bit|a little bit}, {however|but} {other than|instead of} that, {this is|that is} {great|wonderful|fantastic|magnificent|excellent} blog. {A great|An excellent|A fantastic} read. {I’ll|I will} {definitely|certainly} be back.|
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    Greetings! {Very helpful|Very useful} advice {within this|in this particular} {article|post}! {It is the|It’s the} little changes {that make|which will make|that produce|that will make} {the biggest|the largest|the greatest|the most important|the most significant} changes. {Thanks a lot|Thanks|Many thanks} for sharing!|
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